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Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia

Received: 15 February 2018     Accepted: 27 March 2018     Published: 20 April 2018
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Abstract

Anti-streptolysin O (ASO) titer assists for the diagnosis of Group A, Group C and Group G streptococcal infections and their sequele. Reference value of Anti-streptolysin O titer is not available for Ethiopian populations. This study determined the upper limit of normal reference value in apparently healthy children. Participants with a history of streptococal disease were excluded. A total of 127 blood samples were collected from 127 participants with age range of 5-15 years. Serum was used to determine Anti-Streptolysin O-titers. The average ASO Upper limits of Normal (ULN) titer for the total participants was 360 IU/ml with a median 200 IU/ml. The ASO ULN for both male and female children was 320 IU/ml with a median of 200IU/ml. The highest ASO ULN was observed for the age group of 9-12 years (400 IU/ml with median of 200 IU/ml) followed by 360 IU/ml for the age group 5-8 years and age group 13-15 years with a median of 200 IU/ml. This finding shows that ASO ULN are similar to those reported in countries with different climates and populations. Package inserts interpreting ASO titer > 400 IU/ml as recent streptococcal infection is applicable for Ethiopian population.

Published in Journal of Family Medicine and Health Care (Volume 4, Issue 1)
DOI 10.11648/j.jfmhc.20180401.11
Page(s) 1-4
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Children, Apparently Healthy, ASO Titers, Ethiopia

References
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[2] Mandor BI, Asuquo AE, Abia-Bassey L, Benjamin TP, Akpan IA Etuk IS, Eyong ME, Meremiku MM. Antistreptolysin O (ASO) titers and beta-haemolytic streptococcus (BHS) in Children in Calabar, Nigeria. IOSR Journal of Nursing and Health Science. (Jul – Aug 2013); 1 (5): 42-46.
[3] Batzloff M, Yan H, Davies M, et al. Preclinical Evaluation of a Vaccine Based on Conseved Region of M protein that prevents group A Streptococcal Infection, Indian Journal of medical Research, 119suppl, 2004, 104-107.
[4] Andrew CS, Suzanna V, Roselyn R, Joseph K. Michael B. Adam WJ, et al., Normal Ranges of Streptococcal Antibody Titers Are Similar Whether Streptococci Are Endemic to the Setting or Not. Clinical and Vaccine Immunology, Feb. 2009; 16 (5): 172-175.
[5] Shet A and Kaplan EL. Clinical use and interpretation of group A streptococcal antibody tests: a practical approach for the pediatrician or primary care physician. Pediatr. Infect. Dis. J. 2002; 21:420-426.
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[16] Steer AC, Carapetis JR, Nolan TM, Shann F. Systematic review of rheumatic heart disease prevalence in children in developing countries: the role of environmental factors. J Paediatr Child Health. 2002; 38: 229-234.
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Cite This Article
  • APA Style

    Tsegahun Asfaw, Demissew Shenkute, Mihret Tilahun, Nigus Zegeye. (2018). Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia. Journal of Family Medicine and Health Care, 4(1), 1-4. https://doi.org/10.11648/j.jfmhc.20180401.11

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    ACS Style

    Tsegahun Asfaw; Demissew Shenkute; Mihret Tilahun; Nigus Zegeye. Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia. J. Fam. Med. Health Care 2018, 4(1), 1-4. doi: 10.11648/j.jfmhc.20180401.11

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    AMA Style

    Tsegahun Asfaw, Demissew Shenkute, Mihret Tilahun, Nigus Zegeye. Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia. J Fam Med Health Care. 2018;4(1):1-4. doi: 10.11648/j.jfmhc.20180401.11

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  • @article{10.11648/j.jfmhc.20180401.11,
      author = {Tsegahun Asfaw and Demissew Shenkute and Mihret Tilahun and Nigus Zegeye},
      title = {Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia},
      journal = {Journal of Family Medicine and Health Care},
      volume = {4},
      number = {1},
      pages = {1-4},
      doi = {10.11648/j.jfmhc.20180401.11},
      url = {https://doi.org/10.11648/j.jfmhc.20180401.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfmhc.20180401.11},
      abstract = {Anti-streptolysin O (ASO) titer assists for the diagnosis of Group A, Group C and Group G streptococcal infections and their sequele. Reference value of Anti-streptolysin O titer is not available for Ethiopian populations. This study determined the upper limit of normal reference value in apparently healthy children. Participants with a history of streptococal disease were excluded. A total of 127 blood samples were collected from 127 participants with age range of 5-15 years. Serum was used to determine Anti-Streptolysin O-titers. The average ASO Upper limits of Normal (ULN) titer for the total participants was 360 IU/ml with a median 200 IU/ml. The ASO ULN for both male and female children was 320 IU/ml with a median of 200IU/ml. The highest ASO ULN was observed for the age group of 9-12 years (400 IU/ml with median of 200 IU/ml) followed by 360 IU/ml for the age group 5-8 years and age group 13-15 years with a median of 200 IU/ml. This finding shows that ASO ULN are similar to those reported in countries with different climates and populations. Package inserts interpreting ASO titer > 400 IU/ml as recent streptococcal infection is applicable for Ethiopian population.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia
    AU  - Tsegahun Asfaw
    AU  - Demissew Shenkute
    AU  - Mihret Tilahun
    AU  - Nigus Zegeye
    Y1  - 2018/04/20
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    N1  - https://doi.org/10.11648/j.jfmhc.20180401.11
    DO  - 10.11648/j.jfmhc.20180401.11
    T2  - Journal of Family Medicine and Health Care
    JF  - Journal of Family Medicine and Health Care
    JO  - Journal of Family Medicine and Health Care
    SP  - 1
    EP  - 4
    PB  - Science Publishing Group
    SN  - 2469-8342
    UR  - https://doi.org/10.11648/j.jfmhc.20180401.11
    AB  - Anti-streptolysin O (ASO) titer assists for the diagnosis of Group A, Group C and Group G streptococcal infections and their sequele. Reference value of Anti-streptolysin O titer is not available for Ethiopian populations. This study determined the upper limit of normal reference value in apparently healthy children. Participants with a history of streptococal disease were excluded. A total of 127 blood samples were collected from 127 participants with age range of 5-15 years. Serum was used to determine Anti-Streptolysin O-titers. The average ASO Upper limits of Normal (ULN) titer for the total participants was 360 IU/ml with a median 200 IU/ml. The ASO ULN for both male and female children was 320 IU/ml with a median of 200IU/ml. The highest ASO ULN was observed for the age group of 9-12 years (400 IU/ml with median of 200 IU/ml) followed by 360 IU/ml for the age group 5-8 years and age group 13-15 years with a median of 200 IU/ml. This finding shows that ASO ULN are similar to those reported in countries with different climates and populations. Package inserts interpreting ASO titer > 400 IU/ml as recent streptococcal infection is applicable for Ethiopian population.
    VL  - 4
    IS  - 1
    ER  - 

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Author Information
  • Department of Medical Laboratory Science, Debre Berhan University, Debre Berhan, Ethiopia

  • Department of Medical Laboratory Science, Debre Berhan University, Debre Berhan, Ethiopia

  • Department of Medical Laboratory Science, Debre Berhan University, Debre Berhan, Ethiopia

  • Department of Medical Laboratory Science, Debre Berhan University, Debre Berhan, Ethiopia

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